TU Darmstadt / ULB / TUbiblio

Replication and translation of epigenetic information.

Brero, A. and Leonhardt, H. and Cardoso, M. Cristina :
Replication and translation of epigenetic information.
[Online-Edition: http://www.cardoso-lab.org/publications/Brero_2006.pdf]
In: Current topics in microbiology and immunology, 301 pp. 21-44. ISSN 0070-217X
[Article] , (2006)

Official URL: http://www.cardoso-lab.org/publications/Brero_2006.pdf

Abstract

Most cells in multicellular organisms contain identical genetic information but differ in their epigenetic information. The latter is encoded at the molecular level by post-replicative methylation of certain DNA bases (in mammals 5-methyl cytosine at CpG sites) and multiple histone modifications in chromatin. In addition, higher-order chromatin structures are generated during differentiation, which might impact on genome expression and stability. The epigenetic information needs to be "translated" in order to define specific cell types with specific sets of active and inactive genes, collectively called the epigenome. Once established, the epigenome needs to be "replicated" at each cell division cycle, i.e., both genetic and epigenetic information have to be faithfully duplicated, which implies a tight coordination between the DNA replication machinery and epigenetic regulators. In this review, we focus on the molecules and mechanisms responsible for the replication and translation of DNA methylation in mammals as one of the central epigenetic marks.

Item Type: Article
Erschienen: 2006
Creators: Brero, A. and Leonhardt, H. and Cardoso, M. Cristina
Title: Replication and translation of epigenetic information.
Language: English
Abstract:

Most cells in multicellular organisms contain identical genetic information but differ in their epigenetic information. The latter is encoded at the molecular level by post-replicative methylation of certain DNA bases (in mammals 5-methyl cytosine at CpG sites) and multiple histone modifications in chromatin. In addition, higher-order chromatin structures are generated during differentiation, which might impact on genome expression and stability. The epigenetic information needs to be "translated" in order to define specific cell types with specific sets of active and inactive genes, collectively called the epigenome. Once established, the epigenome needs to be "replicated" at each cell division cycle, i.e., both genetic and epigenetic information have to be faithfully duplicated, which implies a tight coordination between the DNA replication machinery and epigenetic regulators. In this review, we focus on the molecules and mechanisms responsible for the replication and translation of DNA methylation in mammals as one of the central epigenetic marks.

Journal or Publication Title: Current topics in microbiology and immunology
Volume: 301
Divisions: 10 Department of Biology
?? fb10_zoologie ??
10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 06 Mar 2010 08:22
Official URL: http://www.cardoso-lab.org/publications/Brero_2006.pdf
Export:

Optionen (nur für Redakteure)

View Item View Item