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Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes

Yameen, Basit ; Ali, Mubarak ; Neumann, Reinhard ; Ensinger, Wolfgang ; Knoll, Wolfgang ; Azzaroni, Omar :
Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes.
[Online-Edition: http://dx.doi.org/10.1021/nl901403u]
In: Nano Letters, 9 (7) pp. 2788-2793.
[Artikel], (2009)

Offizielle URL: http://dx.doi.org/10.1021/nl901403u

Kurzbeschreibung (Abstract)

The creation of switchable and tunable nanodevices displaying transport properties similar to those observed in biological pores poses a major challenge in molecular nanotechnology. Here, we describe the construction of a fully "abiotic" nanodevice whose transport properties can be accurately controlled by manipulating the proton concentration in the surrounding environment. The ionic current switching characteristics displayed by the nanochannels resemble the typical behavior observed in many biological channels that fulfill key pH-dependent transport functions in living organisms, that is, the nanochannel can be switched from an "off" state to an "on" state in response to a pH drop. The construction of such a chemical nanoarchitecture required the integration of stable and ductile macromolecular building blocks constituted of pH-responsive poly(4-vinyl pyridine) brushes into solid state nanopores that could act as gate-keepers managing and constraining the flow of ionic species through the confined environment. In this context, we envision that the integration of environmental stimuli-responsive brushes into solid-state nanochannels would provide a plethora of new chemical alternatives for molecularly design robust signal-responsive "abiotic" devices mimicking the function of proton-gated ion channels commonly encountered in biological membranes.

Typ des Eintrags: Artikel
Erschienen: 2009
Autor(en): Yameen, Basit ; Ali, Mubarak ; Neumann, Reinhard ; Ensinger, Wolfgang ; Knoll, Wolfgang ; Azzaroni, Omar
Titel: Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes
Sprache: Englisch
Kurzbeschreibung (Abstract):

The creation of switchable and tunable nanodevices displaying transport properties similar to those observed in biological pores poses a major challenge in molecular nanotechnology. Here, we describe the construction of a fully "abiotic" nanodevice whose transport properties can be accurately controlled by manipulating the proton concentration in the surrounding environment. The ionic current switching characteristics displayed by the nanochannels resemble the typical behavior observed in many biological channels that fulfill key pH-dependent transport functions in living organisms, that is, the nanochannel can be switched from an "off" state to an "on" state in response to a pH drop. The construction of such a chemical nanoarchitecture required the integration of stable and ductile macromolecular building blocks constituted of pH-responsive poly(4-vinyl pyridine) brushes into solid state nanopores that could act as gate-keepers managing and constraining the flow of ionic species through the confined environment. In this context, we envision that the integration of environmental stimuli-responsive brushes into solid-state nanochannels would provide a plethora of new chemical alternatives for molecularly design robust signal-responsive "abiotic" devices mimicking the function of proton-gated ion channels commonly encountered in biological membranes.

Titel der Zeitschrift, Zeitung oder Schriftenreihe: Nano Letters
Band: 9
(Heft-)Nummer: 7
Verlag: ACS Publications
Fachbereich(e)/-gebiet(e): Fachbereich Material- und Geowissenschaften > Materialwissenschaften > Materialanalytik
Fachbereich Material- und Geowissenschaften > Materialwissenschaften
Fachbereich Material- und Geowissenschaften
Hinterlegungsdatum: 27 Jul 2009 11:36
Offizielle URL: http://dx.doi.org/10.1021/nl901403u
Sponsoren: B.Y. acknowledges support from the Higher Education Commission (HEC) of Pakistan and Deutscher Akademischer Austauschdienst (DAAD) (Code No. A/04/30795)., M.A. thanks the Higher Education Commission (HEC) of Pakistan on receiving partial financial support., O.A. is a CONICET fellow and acknowledges financial support from the Max Planck Society (Germany), the Alexander von Humboldt Stiftung (Germany), and the Centro Interdisciplinario de Nanociencia y Nanotecnologı´a (CINN) (ANPCyT - Argentina).
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