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Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes

Yameen, Basit and Ali, Mubarak and Neumann, Reinhard and Ensinger, Wolfgang and Knoll, Wolfgang and Azzaroni, Omar (2009):
Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes.
In: Nano Letters, ACS Publications, pp. 2788-2793, 9, (7), [Online-Edition: http://dx.doi.org/10.1021/nl901403u],
[Article]

Abstract

The creation of switchable and tunable nanodevices displaying transport properties similar to those observed in biological pores poses a major challenge in molecular nanotechnology. Here, we describe the construction of a fully "abiotic" nanodevice whose transport properties can be accurately controlled by manipulating the proton concentration in the surrounding environment. The ionic current switching characteristics displayed by the nanochannels resemble the typical behavior observed in many biological channels that fulfill key pH-dependent transport functions in living organisms, that is, the nanochannel can be switched from an "off" state to an "on" state in response to a pH drop. The construction of such a chemical nanoarchitecture required the integration of stable and ductile macromolecular building blocks constituted of pH-responsive poly(4-vinyl pyridine) brushes into solid state nanopores that could act as gate-keepers managing and constraining the flow of ionic species through the confined environment. In this context, we envision that the integration of environmental stimuli-responsive brushes into solid-state nanochannels would provide a plethora of new chemical alternatives for molecularly design robust signal-responsive "abiotic" devices mimicking the function of proton-gated ion channels commonly encountered in biological membranes.

Item Type: Article
Erschienen: 2009
Creators: Yameen, Basit and Ali, Mubarak and Neumann, Reinhard and Ensinger, Wolfgang and Knoll, Wolfgang and Azzaroni, Omar
Title: Synthetic Proton-Gated Ion Channels via Single Solid-State Nanochannels Modified with Responsive Polymer Brushes
Language: English
Abstract:

The creation of switchable and tunable nanodevices displaying transport properties similar to those observed in biological pores poses a major challenge in molecular nanotechnology. Here, we describe the construction of a fully "abiotic" nanodevice whose transport properties can be accurately controlled by manipulating the proton concentration in the surrounding environment. The ionic current switching characteristics displayed by the nanochannels resemble the typical behavior observed in many biological channels that fulfill key pH-dependent transport functions in living organisms, that is, the nanochannel can be switched from an "off" state to an "on" state in response to a pH drop. The construction of such a chemical nanoarchitecture required the integration of stable and ductile macromolecular building blocks constituted of pH-responsive poly(4-vinyl pyridine) brushes into solid state nanopores that could act as gate-keepers managing and constraining the flow of ionic species through the confined environment. In this context, we envision that the integration of environmental stimuli-responsive brushes into solid-state nanochannels would provide a plethora of new chemical alternatives for molecularly design robust signal-responsive "abiotic" devices mimicking the function of proton-gated ion channels commonly encountered in biological membranes.

Journal or Publication Title: Nano Letters
Volume: 9
Number: 7
Publisher: ACS Publications
Divisions: 11 Department of Materials and Earth Sciences > Material Science > Material Analytics
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences
Date Deposited: 27 Jul 2009 11:36
Official URL: http://dx.doi.org/10.1021/nl901403u
Funders: B.Y. acknowledges support from the Higher Education Commission (HEC) of Pakistan and Deutscher Akademischer Austauschdienst (DAAD) (Code No. A/04/30795)., M.A. thanks the Higher Education Commission (HEC) of Pakistan on receiving partial financial support., O.A. is a CONICET fellow and acknowledges financial support from the Max Planck Society (Germany), the Alexander von Humboldt Stiftung (Germany), and the Centro Interdisciplinario de Nanociencia y Nanotecnologı´a (CINN) (ANPCyT - Argentina).
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