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Miniaturization of screening devices for the combinatorial development of heterogeneous catalysts

Claus, Peter ; Hönicke, Dieter ; Zech, Torsten :
Miniaturization of screening devices for the combinatorial development of heterogeneous catalysts.
In: Catalysis Today, 67 (4) pp. 319-339.
[Artikel], (2001)

Kurzbeschreibung (Abstract)

The present work is focused on the determination of the advantages, bottlenecks and challenges of miniaturized screening systems which are essential to the success of combinatorial high-throughput methodologies in heterogeneous catalysis. Two different reactor configurations with different degrees of miniaturization were developed for the parallel and fast screening of heterogeneously catalyzed gas phase reactions: a monolithic reactor system acting as a multichannel reactor and a microreaction system based on microfabrication techniques. In both cases, a scanning mass spectrometry technique was successfully applied for quantitative product analysis within 60 s per catalyst. Due to its flexibility and high spatial resolution, this three dimensional scanning MS can be used with different and highly parallel reactor arrays. Many experiments were carried out to study the efficiency and reliability of the different screening systems, with the oxidation of methane, the oxidation of CO, and the oxidative dehydrogenation of i-butane as model reactions. Moreover, chip modules in silicon–glass technology having a number of parallel microchannels were developed, each of them containing a different catalyst. Using this approach, “catalysis-on-a-chip” proved in methane oxidation was possible. Finally, a multibatch reactor consisting of a number of parallel mini autoclaves was developed and tested in the liquid-phase hydrogenation of citral in order to overcome the lack of parallel and fast screening procedures for heterogeneously catalyzed gas–liquid reactions widely spread in the chemical industry.

Typ des Eintrags: Artikel
Erschienen: 2001
Autor(en): Claus, Peter ; Hönicke, Dieter ; Zech, Torsten
Titel: Miniaturization of screening devices for the combinatorial development of heterogeneous catalysts
Sprache: Englisch
Kurzbeschreibung (Abstract):

The present work is focused on the determination of the advantages, bottlenecks and challenges of miniaturized screening systems which are essential to the success of combinatorial high-throughput methodologies in heterogeneous catalysis. Two different reactor configurations with different degrees of miniaturization were developed for the parallel and fast screening of heterogeneously catalyzed gas phase reactions: a monolithic reactor system acting as a multichannel reactor and a microreaction system based on microfabrication techniques. In both cases, a scanning mass spectrometry technique was successfully applied for quantitative product analysis within 60 s per catalyst. Due to its flexibility and high spatial resolution, this three dimensional scanning MS can be used with different and highly parallel reactor arrays. Many experiments were carried out to study the efficiency and reliability of the different screening systems, with the oxidation of methane, the oxidation of CO, and the oxidative dehydrogenation of i-butane as model reactions. Moreover, chip modules in silicon–glass technology having a number of parallel microchannels were developed, each of them containing a different catalyst. Using this approach, “catalysis-on-a-chip” proved in methane oxidation was possible. Finally, a multibatch reactor consisting of a number of parallel mini autoclaves was developed and tested in the liquid-phase hydrogenation of citral in order to overcome the lack of parallel and fast screening procedures for heterogeneously catalyzed gas–liquid reactions widely spread in the chemical industry.

Titel der Zeitschrift, Zeitung oder Schriftenreihe: Catalysis Today
Band: 67
(Heft-)Nummer: 4
Freie Schlagworte: Combinatorial catalysis; High-throughput screening of catalysts; Miniaturization; Scanning mass spectrometry; Microchannel reactor; Catalysis-on-a-chip; Multibatch hydrogenation
Fachbereich(e)/-gebiet(e): Fachbereich Chemie
Fachbereich Chemie > Technische Chemie > Technische Chemie II
Fachbereich Chemie > Technische Chemie
Hinterlegungsdatum: 20 Mär 2009 08:58
ID-Nummer: 10.1016/S0920-5861(01)00326-1
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