Danielyan, L. ; Lourhmati, A. ; Verleysdonk, S. ; Proksch, B. ; Umbreen, S. ; Schmidt, B. ; Gleiter, C. H. (2007)
Angiotensin receptor type 1 blockade in astrocytes decreases hypoxia-induced cytotoxicity and inflammation.
In: Neurochemical Research, 32 (9)
doi: 10.1007/s11064-007-9337-6
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The present study investigated the role of angiotensin receptors (AT-R) in the survival and inflam- matory response of astroglia upon hypoxic injury. Expo- sure of rat astroglial primary cultures (APC) to hypoxic conditions (HC) led to decreased viability of the cells and to a 3.5-fold increase in TNF-alpha release. AT-R type1 (AT1-R) antagonist losartan and its metabolite EXP3174 decrease the LDH release (by 36 ± 9%; 45 ± 6%) from APC under HC. Losartan diminished TNF-alpha release (by 40 ± 15%) and the number of TUNEL-cells by 204 ± 38% under HC, alone and together with angiotensin II (ATII), while EXP3174 was dependent on ATII for its effect on TNF-alpha. The AT2-R antagonist, PD123.319, did not influence the release of LDH and TNF-alpha under normoxic (NC) and HC. These data suggest that AT1-R may decrease the susceptibility of astrocytes to hypoxic injury and their propensity to release TNF-alpha. AT1-R antagonists may therefore be of therapeutic value during hypoxia-associated neurodegeneration.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2007 |
| Autor(en): | Danielyan, L. ; Lourhmati, A. ; Verleysdonk, S. ; Proksch, B. ; Umbreen, S. ; Schmidt, B. ; Gleiter, C. H. |
| Art des Eintrags: | Bibliographie |
| Titel: | Angiotensin receptor type 1 blockade in astrocytes decreases hypoxia-induced cytotoxicity and inflammation |
| Sprache: | Englisch |
| Publikationsjahr: | 2007 |
| Verlag: | Springer |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Neurochemical Research |
| Jahrgang/Volume einer Zeitschrift: | 32 |
| (Heft-)Nummer: | 9 |
| DOI: | 10.1007/s11064-007-9337-6 |
| Kurzbeschreibung (Abstract): | The present study investigated the role of angiotensin receptors (AT-R) in the survival and inflam- matory response of astroglia upon hypoxic injury. Expo- sure of rat astroglial primary cultures (APC) to hypoxic conditions (HC) led to decreased viability of the cells and to a 3.5-fold increase in TNF-alpha release. AT-R type1 (AT1-R) antagonist losartan and its metabolite EXP3174 decrease the LDH release (by 36 ± 9%; 45 ± 6%) from APC under HC. Losartan diminished TNF-alpha release (by 40 ± 15%) and the number of TUNEL-cells by 204 ± 38% under HC, alone and together with angiotensin II (ATII), while EXP3174 was dependent on ATII for its effect on TNF-alpha. The AT2-R antagonist, PD123.319, did not influence the release of LDH and TNF-alpha under normoxic (NC) and HC. These data suggest that AT1-R may decrease the susceptibility of astrocytes to hypoxic injury and their propensity to release TNF-alpha. AT1-R antagonists may therefore be of therapeutic value during hypoxia-associated neurodegeneration. |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie |
| Hinterlegungsdatum: | 20 Nov 2008 08:26 |
| Letzte Änderung: | 20 Feb 2020 13:23 |
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