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The role of Substance P in the defense line of the respiratory tract and neurological manifestations post COVID-19 infection

Mehboob, Riffat ; Oehme, Peter ; Pfaff, Gerhard (2023)
The role of Substance P in the defense line of the respiratory tract and neurological manifestations post COVID-19 infection.
In: Frontiers in Neurology, 2023, 14
doi: 10.26083/tuprints-00023405
Artikel, Zweitveröffentlichung, Verlagsversion

Kurzbeschreibung (Abstract)

Substance P (SP) has been a great interest for scientists due to its unique properties and involvement in various physiological and pathological phenomenon. It took almost a century for the current understanding of this peptide so far. Its role in brain and gut were initially discussed and later on it was widely studied and observed in cardiovascular system, asthma, traumatic brain injury, immune response, vasodilation, behavior, inflammation, arthritis, cancer, airway hyper responsiveness and respiratory disorders. Involvement of SP in sudden perinatal death and COVID-19 has also been discussed which shed light on its vital role in respiratory rhythm regulation and initiation of cytokine storming in COVID-19. This article will provide a comprehensive overview of the researches done to understand the basic functions and involvement of SP in different processes of cell and its association with various diseases. This article describes the historical and scientific journey of SP from its discovery until today, including its future perspectives.

Typ des Eintrags: Artikel
Erschienen: 2023
Autor(en): Mehboob, Riffat ; Oehme, Peter ; Pfaff, Gerhard
Art des Eintrags: Zweitveröffentlichung
Titel: The role of Substance P in the defense line of the respiratory tract and neurological manifestations post COVID-19 infection
Sprache: Englisch
Publikationsjahr: 2023
Ort: Darmstadt
Publikationsdatum der Erstveröffentlichung: 2023
Verlag: Frontiers Media S.A.
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Frontiers in Neurology
Jahrgang/Volume einer Zeitschrift: 14
Kollation: 10 Seiten
DOI: 10.26083/tuprints-00023405
URL / URN: https://tuprints.ulb.tu-darmstadt.de/23405
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Herkunft: Zweitveröffentlichung DeepGreen
Kurzbeschreibung (Abstract):

Substance P (SP) has been a great interest for scientists due to its unique properties and involvement in various physiological and pathological phenomenon. It took almost a century for the current understanding of this peptide so far. Its role in brain and gut were initially discussed and later on it was widely studied and observed in cardiovascular system, asthma, traumatic brain injury, immune response, vasodilation, behavior, inflammation, arthritis, cancer, airway hyper responsiveness and respiratory disorders. Involvement of SP in sudden perinatal death and COVID-19 has also been discussed which shed light on its vital role in respiratory rhythm regulation and initiation of cytokine storming in COVID-19. This article will provide a comprehensive overview of the researches done to understand the basic functions and involvement of SP in different processes of cell and its association with various diseases. This article describes the historical and scientific journey of SP from its discovery until today, including its future perspectives.

Freie Schlagworte: Substance P, COVID-19, lung inflammation, respiratory disorders, cytokine storming
Status: Verlagsversion
URN: urn:nbn:de:tuda-tuprints-234059
Sachgruppe der Dewey Dezimalklassifikatin (DDC): 500 Naturwissenschaften und Mathematik > 540 Chemie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
Fachbereich(e)/-gebiet(e): 07 Fachbereich Chemie
07 Fachbereich Chemie > Eduard Zintl-Institut > Fachgebiet Anorganische Chemie
Hinterlegungsdatum: 11 Apr 2023 11:53
Letzte Änderung: 12 Apr 2023 05:01
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