Zhang, Hui ; Qin, Weihua ; Romero, Hector ; Leonhardt, Heinrich ; Cardoso, M. Cristina (2023)
Heterochromatin organization and phase separation.
In: Nucleus (Austin, Tex.), 14 (1)
doi: 10.1080/19491034.2022.2159142
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
The eukaryotic nucleus displays a variety of membraneless compartments with distinct biomolecular composition and specific cellular activities. Emerging evidence indicates that protein-based liquid-liquid phase separation (LLPS) plays an essential role in the formation and dynamic regulation of heterochromatin compartmentalization. This feature is especially conspicuous at the pericentric heterochromatin domains. In this review, we will describe our understanding of heterochromatin organization and LLPS. In addition, we will highlight the increasing importance of multivalent weak homo- and heteromolecular interactions in LLPS-mediated heterochromatin compartmentalization in the complex environment inside living cells.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Zhang, Hui ; Qin, Weihua ; Romero, Hector ; Leonhardt, Heinrich ; Cardoso, M. Cristina |
| Art des Eintrags: | Bibliographie |
| Titel: | Heterochromatin organization and phase separation |
| Sprache: | Englisch |
| Publikationsjahr: | Dezember 2023 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nucleus (Austin, Tex.) |
| Jahrgang/Volume einer Zeitschrift: | 14 |
| (Heft-)Nummer: | 1 |
| DOI: | 10.1080/19491034.2022.2159142 |
| Kurzbeschreibung (Abstract): | The eukaryotic nucleus displays a variety of membraneless compartments with distinct biomolecular composition and specific cellular activities. Emerging evidence indicates that protein-based liquid-liquid phase separation (LLPS) plays an essential role in the formation and dynamic regulation of heterochromatin compartmentalization. This feature is especially conspicuous at the pericentric heterochromatin domains. In this review, we will describe our understanding of heterochromatin organization and LLPS. In addition, we will highlight the increasing importance of multivalent weak homo- and heteromolecular interactions in LLPS-mediated heterochromatin compartmentalization in the complex environment inside living cells. |
| ID-Nummer: | pmid:36710442 |
| Zusätzliche Informationen: | Artikel-ID: 2159142 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Cell Biology and Epigenetics |
| Hinterlegungsdatum: | 06 Feb 2023 13:24 |
| Letzte Änderung: | 06 Feb 2023 13:24 |
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