Mukhina, Tetiana ; Pabst, Georg ; Ruysschaert, Jean-Marie ; Brezesinski, Gerald ; Schneck, Emanuel (2022)
pH-Dependent physicochemical properties of ornithine lipid in mono- and bilayers.
In: Physical Chemistry Chemical Physics, 24 (37)
doi: 10.1039/D2CP01045C
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
In certain bacteria, phosphatidylethanolamine lipids (PEL) get largely replaced by phosphate-free ornithine lipids (OL) under conditions of phosphate starvation. It has so far been unknown how much these two lipid types deviate in their physicochemical properties, and how strongly bacteria thus have to adapt in order to compensate for the difference. Here, we use differential scanning calorimetry, X-ray scattering, and X-ray fluorescence to investigate the properties of OL with saturated C14 alkyl chains in mono- and bilayers. OL is found to have a greater tendency than chain-analogous PEL to form ordered structures and, in contrast to PEL, even a molecular superlattice based on a hydrogen bonding network between the headgroups. This superlattice is virtually electrically uncharged and persists over a wide pH range. Our results indicate that OL and PEL behave very differently in ordered single-component membranes but may behave more similarly in fluid multicomponent membranes.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Mukhina, Tetiana ; Pabst, Georg ; Ruysschaert, Jean-Marie ; Brezesinski, Gerald ; Schneck, Emanuel |
| Art des Eintrags: | Bibliographie |
| Titel: | pH-Dependent physicochemical properties of ornithine lipid in mono- and bilayers |
| Sprache: | Englisch |
| Publikationsjahr: | 8 September 2022 |
| Verlag: | Royal Society of Chemistry |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Physical Chemistry Chemical Physics |
| Jahrgang/Volume einer Zeitschrift: | 24 |
| (Heft-)Nummer: | 37 |
| DOI: | 10.1039/D2CP01045C |
| Kurzbeschreibung (Abstract): | In certain bacteria, phosphatidylethanolamine lipids (PEL) get largely replaced by phosphate-free ornithine lipids (OL) under conditions of phosphate starvation. It has so far been unknown how much these two lipid types deviate in their physicochemical properties, and how strongly bacteria thus have to adapt in order to compensate for the difference. Here, we use differential scanning calorimetry, X-ray scattering, and X-ray fluorescence to investigate the properties of OL with saturated C14 alkyl chains in mono- and bilayers. OL is found to have a greater tendency than chain-analogous PEL to form ordered structures and, in contrast to PEL, even a molecular superlattice based on a hydrogen bonding network between the headgroups. This superlattice is virtually electrically uncharged and persists over a wide pH range. Our results indicate that OL and PEL behave very differently in ordered single-component membranes but may behave more similarly in fluid multicomponent membranes. |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) > Physik biologischer weicher Materie 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) > Theorie weicher Materie |
| Hinterlegungsdatum: | 10 Okt 2022 12:59 |
| Letzte Änderung: | 11 Apr 2023 13:29 |
| PPN: | 506755061 |
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