Kolobynina, Ksenia G. ; Rapp, Alexander ; Cardoso, M. Cristina (2022)
Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair.
In: Frontiers in cell and developmental biology, 10
doi: 10.3389/fcell.2022.928113
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR) pathway. In turn, proceeding DDR changes the chromatin at the damaged site and across large fractions of the genome. Ubiquitination, besides phosphorylation and methylation, was characterized as an important chromatin post-translational modification (PTM) occurring at the DNA damage site and persisting during the duration of the DDR. Ubiquitination appears to function as a highly versatile "signal-response" network involving several types of players performing various functions. Here we discuss how ubiquitin modifiers fine-tune the DNA damage recognition and response and how the interaction with other chromatin modifications ensures cell survival.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Kolobynina, Ksenia G. ; Rapp, Alexander ; Cardoso, M. Cristina |
| Art des Eintrags: | Bibliographie |
| Titel: | Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair |
| Sprache: | Englisch |
| Publikationsjahr: | 5 Juli 2022 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in cell and developmental biology |
| Jahrgang/Volume einer Zeitschrift: | 10 |
| DOI: | 10.3389/fcell.2022.928113 |
| Kurzbeschreibung (Abstract): | Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR) pathway. In turn, proceeding DDR changes the chromatin at the damaged site and across large fractions of the genome. Ubiquitination, besides phosphorylation and methylation, was characterized as an important chromatin post-translational modification (PTM) occurring at the DNA damage site and persisting during the duration of the DDR. Ubiquitination appears to function as a highly versatile "signal-response" network involving several types of players performing various functions. Here we discuss how ubiquitin modifiers fine-tune the DNA damage recognition and response and how the interaction with other chromatin modifications ensures cell survival. |
| ID-Nummer: | pmid:35865631 |
| Zusätzliche Informationen: | Artikel-ID: 928113 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Cell Biology and Epigenetics |
| Hinterlegungsdatum: | 26 Jul 2022 07:00 |
| Letzte Änderung: | 06 Okt 2022 08:40 |
| PPN: | 497524449 |
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