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Carbon Ion Radiobiology

Tinganelli, Walter ; Durante, Marco (2022)
Carbon Ion Radiobiology.
In: Cancers, 2022, 12 (10)
doi: 10.26083/tuprints-00016188
Artikel, Zweitveröffentlichung, Verlagsversion

Kurzbeschreibung (Abstract)

Radiotherapy using accelerated charged particles is rapidly growing worldwide. About 85% of the cancer patients receiving particle therapy are irradiated with protons, which have physical advantages compared to X-rays but a similar biological response. In addition to the ballistic advantages, heavy ions present specific radiobiological features that can make them attractive for treating radioresistant, hypoxic tumors. An ideal heavy ion should have lower toxicity in the entrance channel (normal tissue) and be exquisitely effective in the target region (tumor). Carbon ions have been chosen because they represent the best combination in this direction. Normal tissue toxicities and second cancer risk are similar to those observed in conventional radiotherapy. In the target region, they have increased relative biological effectiveness and a reduced oxygen enhancement ratio compared to X-rays. Some radiobiological properties of densely ionizing carbon ions are so distinct from X-rays and protons that they can be considered as a different “drug” in oncology, and may elicit favorable responses such as an increased immune response and reduced angiogenesis and metastatic potential. The radiobiological properties of carbon ions should guide patient selection and treatment protocols to achieve optimal clinical results.

Typ des Eintrags: Artikel
Erschienen: 2022
Autor(en): Tinganelli, Walter ; Durante, Marco
Art des Eintrags: Zweitveröffentlichung
Titel: Carbon Ion Radiobiology
Sprache: Englisch
Publikationsjahr: 2022
Publikationsdatum der Erstveröffentlichung: 2022
Verlag: MDPI
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Cancers
Jahrgang/Volume einer Zeitschrift: 12
(Heft-)Nummer: 10
Kollation: 37 Seiten
DOI: 10.26083/tuprints-00016188
URL / URN: https://tuprints.ulb.tu-darmstadt.de/16188
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Herkunft: Zweitveröffentlichung
Kurzbeschreibung (Abstract):

Radiotherapy using accelerated charged particles is rapidly growing worldwide. About 85% of the cancer patients receiving particle therapy are irradiated with protons, which have physical advantages compared to X-rays but a similar biological response. In addition to the ballistic advantages, heavy ions present specific radiobiological features that can make them attractive for treating radioresistant, hypoxic tumors. An ideal heavy ion should have lower toxicity in the entrance channel (normal tissue) and be exquisitely effective in the target region (tumor). Carbon ions have been chosen because they represent the best combination in this direction. Normal tissue toxicities and second cancer risk are similar to those observed in conventional radiotherapy. In the target region, they have increased relative biological effectiveness and a reduced oxygen enhancement ratio compared to X-rays. Some radiobiological properties of densely ionizing carbon ions are so distinct from X-rays and protons that they can be considered as a different “drug” in oncology, and may elicit favorable responses such as an increased immune response and reduced angiogenesis and metastatic potential. The radiobiological properties of carbon ions should guide patient selection and treatment protocols to achieve optimal clinical results.

Freie Schlagworte: carbon ions, particle therapy, radiotherapy, radiobiology, hypoxia, RBE, immunotherapy, metastasis
Status: Verlagsversion
URN: urn:nbn:de:tuda-tuprints-161883
Sachgruppe der Dewey Dezimalklassifikatin (DDC): 500 Naturwissenschaften und Mathematik > 530 Physik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit
Fachbereich(e)/-gebiet(e): 05 Fachbereich Physik
05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM)
Hinterlegungsdatum: 09 Feb 2022 14:50
Letzte Änderung: 10 Feb 2022 10:26
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