Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas (2022)
Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study.
In: Crystals, 2022, 10 (5)
doi: 10.26083/tuprints-00016973
Artikel, Zweitveröffentlichung, Verlagsversion
Kurzbeschreibung (Abstract)
β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Geisler, Ramsia ; Prévost, Sylvain ; Dattani, Rajeev ; Hellweg, Thomas |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study |
| Sprache: | Englisch |
| Publikationsjahr: | 2022 |
| Publikationsdatum der Erstveröffentlichung: | 2022 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Crystals |
| Jahrgang/Volume einer Zeitschrift: | 10 |
| (Heft-)Nummer: | 5 |
| Kollation: | 15 Seiten |
| DOI: | 10.26083/tuprints-00016973 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/16973 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung |
| Kurzbeschreibung (Abstract): | β-aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin β-aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the β-aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures. |
| Freie Schlagworte: | saponin, β-aescin, β-escin, lipid membrane, bicelle, nanodisk, wide-angle X-ray scattering, biosurfactant, ibuprofen |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-169736 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) > Soft Matter at Interfaces (SMI) |
| Hinterlegungsdatum: | 09 Feb 2022 15:18 |
| Letzte Änderung: | 10 Feb 2022 10:26 |
| PPN: | |
| Zugehörige Links: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum