Fischer, Sandra ; Di Liddo, Antonella ; Taylor, Katarzyna ; Gerhardus, Jamina S. ; Sobczak, Krzysztof ; Zarnack, Kathi ; Weigand, Julia E. (2020)
Muscleblind-like 2 controls the hypoxia response of cancer cells.
In: RNA (New York, N.Y.), 26 (5)
doi: 10.1261/rna.073353.119
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Hypoxia is a hallmark of solid cancers, supporting proliferation, angiogenesis, and escape from apoptosis. There is still limited understanding of how cancer cells adapt to hypoxic conditions and survive. We analyzed transcriptome changes of human lung and breast cancer cells under chronic hypoxia. Hypoxia induced highly concordant changes in transcript abundance, but divergent splicing responses, underlining the cell type-specificity of alternative splicing programs. While RNA-binding proteins were predominantly reduced, hypoxia specifically induced muscleblind-like protein 2 (MBNL2). Strikingly, MBNL2 induction was critical for hypoxia adaptation by controlling the transcript abundance of hypoxia response genes, such as vascular endothelial growth factor A ( MBNL2 depletion reduced the proliferation and migration of cancer cells, demonstrating an important role of MBNL2 as cancer driver. Hypoxia control is specific for MBNL2 and not shared by its paralog MBNL1. Thus, our study revealed MBNL2 as central mediator of cancer cell responses to hypoxia, regulating the expression and alternative splicing of hypoxia-induced genes.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2020 |
| Autor(en): | Fischer, Sandra ; Di Liddo, Antonella ; Taylor, Katarzyna ; Gerhardus, Jamina S. ; Sobczak, Krzysztof ; Zarnack, Kathi ; Weigand, Julia E. |
| Art des Eintrags: | Bibliographie |
| Titel: | Muscleblind-like 2 controls the hypoxia response of cancer cells |
| Sprache: | Englisch |
| Publikationsjahr: | Mai 2020 |
| Verlag: | Cold Spring Harbor Laboratory Press / RNA Society |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | RNA (New York, N.Y.) |
| Jahrgang/Volume einer Zeitschrift: | 26 |
| (Heft-)Nummer: | 5 |
| DOI: | 10.1261/rna.073353.119 |
| Kurzbeschreibung (Abstract): | Hypoxia is a hallmark of solid cancers, supporting proliferation, angiogenesis, and escape from apoptosis. There is still limited understanding of how cancer cells adapt to hypoxic conditions and survive. We analyzed transcriptome changes of human lung and breast cancer cells under chronic hypoxia. Hypoxia induced highly concordant changes in transcript abundance, but divergent splicing responses, underlining the cell type-specificity of alternative splicing programs. While RNA-binding proteins were predominantly reduced, hypoxia specifically induced muscleblind-like protein 2 (MBNL2). Strikingly, MBNL2 induction was critical for hypoxia adaptation by controlling the transcript abundance of hypoxia response genes, such as vascular endothelial growth factor A ( MBNL2 depletion reduced the proliferation and migration of cancer cells, demonstrating an important role of MBNL2 as cancer driver. Hypoxia control is specific for MBNL2 and not shared by its paralog MBNL1. Thus, our study revealed MBNL2 as central mediator of cancer cell responses to hypoxia, regulating the expression and alternative splicing of hypoxia-induced genes. |
| ID-Nummer: | pmid:32127384 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 16 Fachbereich Maschinenbau 16 Fachbereich Maschinenbau > Institut für Druckmaschinen und Druckverfahren (IDD) 10 Fachbereich Biologie > RNA Biochemie |
| Hinterlegungsdatum: | 05 Mär 2021 08:14 |
| Letzte Änderung: | 26 Sep 2022 05:50 |
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