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MeCP2 and Chromatin Compartmentalization

Schmidt, Annika ; Zhang, Hui ; Cardoso, M. Cristina (2020):
MeCP2 and Chromatin Compartmentalization.
In: Cells, 9 (4), MDPI, ISSN 2073-4409,
DOI: 10.25534/tuprints-00013360,
[Article]

Abstract

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.

Item Type: Article
Erschienen: 2020
Creators: Schmidt, Annika ; Zhang, Hui ; Cardoso, M. Cristina
Origin: Secondary publication via sponsored Golden Open Access
Title: MeCP2 and Chromatin Compartmentalization
Language: English
Abstract:

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.

Journal or Publication Title: Cells
Journal volume: 9
Number: 4
Publisher: MDPI
Divisions: 10 Department of Biology
10 Department of Biology > Cell Biology and Epigenetics
Date Deposited: 25 Aug 2020 09:22
DOI: 10.25534/tuprints-00013360
Official URL: https://doi.org/10.3390/cells9040878
URN: urn:nbn:de:tuda-tuprints-133604
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