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Impact of Surface Charge Directionality on Membrane Potential in Multi-ionic Systems

Ramirez, Patricio and Cervera, Javier and Ali, Mubarak and Nasir, Saima and Ensinger, Wolfgang and Mafe, Salvador (2020):
Impact of Surface Charge Directionality on Membrane Potential in Multi-ionic Systems.
In: The Journal of Physical Chemistry Letters, 11 (7), pp. 2530-2534. ACS Publications, ISSN 1948-7185,
DOI: 10.1021/acs.jpclett.0c00554,
[Article]

Abstract

The membrane potential (Vmem), defined as the electric potential difference across a membrane flanked by two different salt solutions, is central to electrochemical energy harvesting and conversion. Also, Vmem and the ionic concentrations that establish it are important to biophysical chemistry because they regulate crucial cell processes. We study experimentally and theoretically the salt dependence of Vmem in single conical nanopores for the case of multi-ionic systems of different ionic charge numbers. The major advances of this work are (i) to measure Vmem using a series of ions (Na+, K+, Ca2+, Cl–, and SO42–) that are of interest to both energy conversion and cell biochemistry, (ii) to describe the physicochemical effects resulting from the nanostructure asymmetry, (iii) to develop a theoretical model for multi-ionic systems, and (iv) to quantify the contributions of the liquid junction potentials established in the salt bridges to the total cell membrane potential.

Item Type: Article
Erschienen: 2020
Creators: Ramirez, Patricio and Cervera, Javier and Ali, Mubarak and Nasir, Saima and Ensinger, Wolfgang and Mafe, Salvador
Title: Impact of Surface Charge Directionality on Membrane Potential in Multi-ionic Systems
Language: English
Abstract:

The membrane potential (Vmem), defined as the electric potential difference across a membrane flanked by two different salt solutions, is central to electrochemical energy harvesting and conversion. Also, Vmem and the ionic concentrations that establish it are important to biophysical chemistry because they regulate crucial cell processes. We study experimentally and theoretically the salt dependence of Vmem in single conical nanopores for the case of multi-ionic systems of different ionic charge numbers. The major advances of this work are (i) to measure Vmem using a series of ions (Na+, K+, Ca2+, Cl–, and SO42–) that are of interest to both energy conversion and cell biochemistry, (ii) to describe the physicochemical effects resulting from the nanostructure asymmetry, (iii) to develop a theoretical model for multi-ionic systems, and (iv) to quantify the contributions of the liquid junction potentials established in the salt bridges to the total cell membrane potential.

Journal or Publication Title: The Journal of Physical Chemistry Letters
Journal volume: 11
Number: 7
Publisher: ACS Publications
Divisions: 11 Department of Materials and Earth Sciences
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences > Material Science > Material Analytics
Date Deposited: 04 Jun 2020 05:41
DOI: 10.1021/acs.jpclett.0c00554
Official URL: https://doi.org/10.1021/acs.jpclett.0c00554
Projects: M.A., S.N., and W.E. gratefully acknowledge the financial support from the Hessen State Ministry of Higher Education, Research and the Arts (Germany), LOEWE Project iNAPO., The heavy ion irradiation of polymer membranes are based on a UMAT experiment, which was performed at the X0-beamline of the UNILAC at the GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany) in the frame of FAIR Phase-0., P.R., J.C., and S.M. acknowledge the funding from the Ministerio de Economia y Competitividad and the European Regional Development Funds (FEDER), Project PGC2018-097359-B-I00.
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