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Apatite Forming Ability and Dissolution Behavior of Boron- and Calcium-Modified Silicon Oxycarbides in Comparison to Silicate Bioactive Glass

Xie, Fangtong and Gonzalo-Juan, Isabel and Arango-Ospina, Marcela and Riedel, Ralf and Boccaccini, Aldo R. and Ionescu, Emanuel (2019):
Apatite Forming Ability and Dissolution Behavior of Boron- and Calcium-Modified Silicon Oxycarbides in Comparison to Silicate Bioactive Glass.
In: ACS Biomaterials Science & Engineering, 5 (10), American Chemical Society (ACS), pp. 5337-5347, ISSN 2373-9878,
DOI: 10.1021/acsbiomaterials.9b00816,
[Online-Edition: https://pubs.acs.org/doi/10.1021/acsbiomaterials.9b00816],
[Article]

Abstract

The bioactivity of Ca and/or B modified silicon oxycarbides has been assessed in vitro upon immersion in SBF (simulated body fluid). In the context of the present work, bioactivity refers to the likeliness of hydroxyapatite crystallization (biomineralization) on the surface of a material when in contact with physiological fluids. The incorporation of Ca and B into the silicon oxycarbide glass network is found to increase its bioactivity, which seems to scale with the content of Ca; thus, SiOC glass with a relatively large Ca/Si molar ratio (i.e., 0.12) is shown to exhibit bioactive characteristics similar to those of the benchmark silicate bioactive glass of 45S5 composition. The release kinetics of the SiOC glasses modified with Ca and/or B during the SBF test was studied by inductively coupled plasma-optical emission spectroscopy. It has been observed that the Si release kinetics can be correlated with the Ca content in the SiOC glasses: SiOC based glasses modified with Ca exhibited low Si release activation energies (i.e., 0.07 eV), being comparable to that of 45S5 bioactive glass (i.e., 0.04 eV); whereas silicon oxycarbides without Ca modification showed higher activation energies for Si release (i.e., 0.27 eV).

Item Type: Article
Erschienen: 2019
Creators: Xie, Fangtong and Gonzalo-Juan, Isabel and Arango-Ospina, Marcela and Riedel, Ralf and Boccaccini, Aldo R. and Ionescu, Emanuel
Title: Apatite Forming Ability and Dissolution Behavior of Boron- and Calcium-Modified Silicon Oxycarbides in Comparison to Silicate Bioactive Glass
Language: English
Abstract:

The bioactivity of Ca and/or B modified silicon oxycarbides has been assessed in vitro upon immersion in SBF (simulated body fluid). In the context of the present work, bioactivity refers to the likeliness of hydroxyapatite crystallization (biomineralization) on the surface of a material when in contact with physiological fluids. The incorporation of Ca and B into the silicon oxycarbide glass network is found to increase its bioactivity, which seems to scale with the content of Ca; thus, SiOC glass with a relatively large Ca/Si molar ratio (i.e., 0.12) is shown to exhibit bioactive characteristics similar to those of the benchmark silicate bioactive glass of 45S5 composition. The release kinetics of the SiOC glasses modified with Ca and/or B during the SBF test was studied by inductively coupled plasma-optical emission spectroscopy. It has been observed that the Si release kinetics can be correlated with the Ca content in the SiOC glasses: SiOC based glasses modified with Ca exhibited low Si release activation energies (i.e., 0.07 eV), being comparable to that of 45S5 bioactive glass (i.e., 0.04 eV); whereas silicon oxycarbides without Ca modification showed higher activation energies for Si release (i.e., 0.27 eV).

Journal or Publication Title: ACS Biomaterials Science & Engineering
Volume: 5
Number: 10
Publisher: American Chemical Society (ACS)
Uncontrolled Keywords: Bioactivity; silicon oxycarbide; network connectivity; bioactive glass; in-vitro; carbonated hydroxyapatite; bone; cytotoxicity; precursors; energetics; particles; composite; ceramics; powders
Divisions: 11 Department of Materials and Earth Sciences
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences > Material Science > Dispersive Solids
Date Deposited: 30 Oct 2019 07:46
DOI: 10.1021/acsbiomaterials.9b00816
Official URL: https://pubs.acs.org/doi/10.1021/acsbiomaterials.9b00816
Projects: German Research Foundation (DFG), Grant Number: 317658328, COST Action "Smart Inorganic Polymers", Grant Number: CM1302
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