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Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project

Ensinger, Wolfgang (2018):
Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project.
In: Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology, In: 3rd World Congress on Recent Advances in Nanotechnology (RAN'18), Budapest, Hungary, April 10 - 12, 2018, ISSN 2371-5308,
DOI: 10.11159/icnb18.104,
[Online-Edition: https://doi.org/10.11159/icnb18.104],
[Conference or Workshop Item]

Abstract

Analyzing biologically relevant molecules is an important aspect of medical diagnostics. The iNAPO project aims at developing a device that is able to specifically detect and quantitatively analyze biomolecules. An example is tumor markers that are emitted by the tumor at elevated levels and can be found in body liquids. The analyzer device core consists of a polymer foil containing a nanopore. In analogy to biological nanopores that control e.g. mass transfer into and out of a cell, the biomimetic artificial nanopore allows the passage of ions of an aqueous electrolyte in an electrochemical two - compartment cell from one compartment to the next one under the influence of an electrical field. When the nanopore wall contains certain immobilized molecules that specifically react with the biomolecules to be analyzed, the ionic current is influenced. The difference in th e current can directly be correlated to the presence and the quantity of the biomolecule. As an example, the measurement of small quantities of histamine, the well known neurotransmitter, is shown.

Item Type: Conference or Workshop Item
Erschienen: 2018
Creators: Ensinger, Wolfgang
Title: Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project
Language: English
Abstract:

Analyzing biologically relevant molecules is an important aspect of medical diagnostics. The iNAPO project aims at developing a device that is able to specifically detect and quantitatively analyze biomolecules. An example is tumor markers that are emitted by the tumor at elevated levels and can be found in body liquids. The analyzer device core consists of a polymer foil containing a nanopore. In analogy to biological nanopores that control e.g. mass transfer into and out of a cell, the biomimetic artificial nanopore allows the passage of ions of an aqueous electrolyte in an electrochemical two - compartment cell from one compartment to the next one under the influence of an electrical field. When the nanopore wall contains certain immobilized molecules that specifically react with the biomolecules to be analyzed, the ionic current is influenced. The difference in th e current can directly be correlated to the presence and the quantity of the biomolecule. As an example, the measurement of small quantities of histamine, the well known neurotransmitter, is shown.

Title of Book: Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology
Uncontrolled Keywords: Nanopores, Ion Conduction, Track Etching Technique, Biomolecular Sensor, Neurotransmitter, Histamine
Divisions: 11 Department of Materials and Earth Sciences
11 Department of Materials and Earth Sciences > Material Science
11 Department of Materials and Earth Sciences > Material Science > Material Analytics
Event Title: 3rd World Congress on Recent Advances in Nanotechnology (RAN'18)
Event Location: Budapest, Hungary
Event Dates: April 10 - 12, 2018
Date Deposited: 11 Dec 2018 12:41
DOI: 10.11159/icnb18.104
Official URL: https://doi.org/10.11159/icnb18.104
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