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Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project

Ensinger, Wolfgang (2018)
Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project.
3rd World Congress on Recent Advances in Nanotechnology (RAN'18). Budapest, Hungary (April 10 - 12, 2018)
doi: 10.11159/icnb18.104
Konferenzveröffentlichung, Bibliographie

Kurzbeschreibung (Abstract)

Analyzing biologically relevant molecules is an important aspect of medical diagnostics. The iNAPO project aims at developing a device that is able to specifically detect and quantitatively analyze biomolecules. An example is tumor markers that are emitted by the tumor at elevated levels and can be found in body liquids. The analyzer device core consists of a polymer foil containing a nanopore. In analogy to biological nanopores that control e.g. mass transfer into and out of a cell, the biomimetic artificial nanopore allows the passage of ions of an aqueous electrolyte in an electrochemical two - compartment cell from one compartment to the next one under the influence of an electrical field. When the nanopore wall contains certain immobilized molecules that specifically react with the biomolecules to be analyzed, the ionic current is influenced. The difference in th e current can directly be correlated to the presence and the quantity of the biomolecule. As an example, the measurement of small quantities of histamine, the well known neurotransmitter, is shown.

Typ des Eintrags: Konferenzveröffentlichung
Erschienen: 2018
Autor(en): Ensinger, Wolfgang
Art des Eintrags: Bibliographie
Titel: Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project
Sprache: Englisch
Publikationsjahr: 2018
Buchtitel: Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology
Veranstaltungstitel: 3rd World Congress on Recent Advances in Nanotechnology (RAN'18)
Veranstaltungsort: Budapest, Hungary
Veranstaltungsdatum: April 10 - 12, 2018
DOI: 10.11159/icnb18.104
URL / URN: https://doi.org/10.11159/icnb18.104
Kurzbeschreibung (Abstract):

Analyzing biologically relevant molecules is an important aspect of medical diagnostics. The iNAPO project aims at developing a device that is able to specifically detect and quantitatively analyze biomolecules. An example is tumor markers that are emitted by the tumor at elevated levels and can be found in body liquids. The analyzer device core consists of a polymer foil containing a nanopore. In analogy to biological nanopores that control e.g. mass transfer into and out of a cell, the biomimetic artificial nanopore allows the passage of ions of an aqueous electrolyte in an electrochemical two - compartment cell from one compartment to the next one under the influence of an electrical field. When the nanopore wall contains certain immobilized molecules that specifically react with the biomolecules to be analyzed, the ionic current is influenced. The difference in th e current can directly be correlated to the presence and the quantity of the biomolecule. As an example, the measurement of small quantities of histamine, the well known neurotransmitter, is shown.

Freie Schlagworte: Nanopores, Ion Conduction, Track Etching Technique, Biomolecular Sensor, Neurotransmitter, Histamine
Fachbereich(e)/-gebiet(e): 11 Fachbereich Material- und Geowissenschaften
11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft
11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Materialanalytik
Hinterlegungsdatum: 11 Dez 2018 12:41
Letzte Änderung: 11 Dez 2018 12:41
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