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CAD of Osteoporosis in Vertebrae Using Dual-energy CT

Wesarg, Stefan and Kafchitsas, Konstantinos and Erdt, Marius and Khan, M. Fawad (2010):
CAD of Osteoporosis in Vertebrae Using Dual-energy CT.
IEEE Computer Society, Los Alamitos, Calif., In: Twenty-Third IEEE Symposium on Computer-Based Medical Systems, [Conference or Workshop Item]

Abstract

The assessment of bone mineral density (BMD) in vertebrae is critical for the diagnosis of osteoporosis. Recent developments in dual-source CT allow for the simultaneous acquisition of two image data sets with different X-ray tube energies - dual-energy CT (DECT). We present a comprehensive approach for assessing the density of the trabecular bone in vertebrae of the spine based on DECT image data. For this, we apply and combine methods from different areas: the deformation of a template mesh for delineating the structures of interest, a biophysical model of the trabecular bone for the computation of BMD values, and different visualization approaches for the display of the results. In addition, we investigate the correlation between the computed BMD values with concurrently measured pull-out forces for pedicle screws. We show that there is a linear correlation between both measures and thus, DECT provides correct BMD values for the trabecular bone. We conclude that our approach enables the radiologist to diagnose osteoporosis based on DECT image data which has the potential to replace the current gold standard dual-energy X-ray absorptiometry.

Item Type: Conference or Workshop Item
Erschienen: 2010
Creators: Wesarg, Stefan and Kafchitsas, Konstantinos and Erdt, Marius and Khan, M. Fawad
Title: CAD of Osteoporosis in Vertebrae Using Dual-energy CT
Language: English
Abstract:

The assessment of bone mineral density (BMD) in vertebrae is critical for the diagnosis of osteoporosis. Recent developments in dual-source CT allow for the simultaneous acquisition of two image data sets with different X-ray tube energies - dual-energy CT (DECT). We present a comprehensive approach for assessing the density of the trabecular bone in vertebrae of the spine based on DECT image data. For this, we apply and combine methods from different areas: the deformation of a template mesh for delineating the structures of interest, a biophysical model of the trabecular bone for the computation of BMD values, and different visualization approaches for the display of the results. In addition, we investigate the correlation between the computed BMD values with concurrently measured pull-out forces for pedicle screws. We show that there is a linear correlation between both measures and thus, DECT provides correct BMD values for the trabecular bone. We conclude that our approach enables the radiologist to diagnose osteoporosis based on DECT image data which has the potential to replace the current gold standard dual-energy X-ray absorptiometry.

Publisher: IEEE Computer Society, Los Alamitos, Calif.
Uncontrolled Keywords: Forschungsgruppe Medical Computing (MECO), Computer aided diagnosis, Computed tomography (CT), Medical image processing, Bone mineral density (BMD)
Divisions: 20 Department of Computer Science
20 Department of Computer Science > Interactive Graphics Systems
Event Title: Twenty-Third IEEE Symposium on Computer-Based Medical Systems
Date Deposited: 12 Nov 2018 11:16
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